The transmission of information in cells often involves the modification of proteins by the addition of phosphate groups, a process termed phosphorylation. Phosphorylation is catalyzed by protein kinases, which themselves often require phosphorylation for their activation. Some kinases auto-activate by phosphorylating their own activation loop, a process that is usually accomplished by a second copy of the same protein. In work published in Proceedings of the National Academy of Sciences (PNAS), the lab of Thomas Leonard has discovered, unexpectedly, that Protein kinase D (PKD) activates itself without the need for another copy of PKD.
During infection, specialized cells of our innate immune system mount an immediate response to combat invading pathogens. The activation of these immune cells by interferon signaling is key to the resolution of infection. How interferon signaling interacts with other cellular signaling pathways is unclear. The lab of Thomas Decker has now studied the interaction between interferon and stress signaling. Their findings, published in Science Signaling, show that cross-talk between the two pathways modulates immunity in response to infections.
The Austrian Federal Ministry of Education, Science and Research has awarded a ‘Data Life’ grant to the Max Perutz Labs and the University of Vienna. The €1.9 million grant will be used to provide high-performance data storage capacity over the next few years.
Chromosomal instability (CIN) is detrimental for cellular fitness and is a hallmark of the majority of solid tumors. How cells adjust to this instability to ensure survival is poorly understood. The lab of Christopher Campbell has now studied the long-term adaptation to CIN using yeast cells. They found that cells accumulate mutations over time that help them to alleviate the negative effects of CIN. The work is published in The EMBO Journal.
SPOC domains are protein domains found across eukaryotes. SPOC containing proteins are associated with transcription regulation, development and differentiation. In their latest study, the lab of Dea Slade has now studied all known SPOC containing human proteins. They discovered that the SPOC domain is universally able to read phosphorylation marks in the C-terminal domain of RNA polymerase II, but that subfamilies of SPOC proteins recognize different patterns of CTD marks and bind to additional proteins. The study is published in Nature Communications.
Nuclear pore complexes (NPCs) are the gateways between the nucleus and the cytoplasm. How the individual components assemble into a functional pore is not understood. In a new study, published in Nature, Max Perutz Labs group leader Shotaro Otsuka and the lab of Jan Ellenberg (European Molecular Biology Laboratory, EMBL) provide the first step-by-step guide to NPC assembly. In the future, their approach could be applied to investigate the assembly mechanisms of other molecular machines in the cell.
The Max Perutz Labs are embedded in the Vienna BioCenter, providing access to outstanding core facilities shared by all members of the campus in addition to facilities unique to our institute.
With a strong molecular focus and a diversity of model organisms, we aim to bridge basic research with biomedicine.
To honour an extraordinary teacher and scientist, the Max Perutz Labs were named after Max Ferdinand Perutz, who, together with John C. Kendrew, was awarded the 1962 Nobel Prize in Chemistry for his studies on the structure of globular proteins ...
The Max Perutz Labs are an international research institution in which people from all over the world come together to conduct scientific research. The Perutz recognizes and respects diversity as an important asset in establishing an inclusive and productive work environment for all parties, may it be students, scientists or support staff. We are committed to a workplace that values diversity and internationality, where people from various backgrounds and perspectives feel welcome and are supported in a safe environment. Whether it be race, ethnicity, national origin, religion, social background, age, gender, sexual orientation or disability - we aim to establish a community in which everyone feels included and is treated fairly and respectfully. We believe that there is always room for improvement and that a statement is worth nothing without action, but we continuously strive to do better and encourage every individual to play an active role in creating this environment.
The Max Perutz Labs seek to educate students to think critically and analytically, challenge them to set ambitious goals, and instill in them both broad horizons and deep understanding. In doing so, we aspire to furnish them with the necessary knowledge and skills to push forward the frontiers of 21st century biomedical science.