Paralogous proteins have evolved from gene or whole genome duplications and may provide an insurance policy for deleterious mutations. Why some paralogous proteins exist, however, remains somewhat enigmatic, as they consume substantial cellular energy resources despite often having homologous functions. In a new study published in Nature Communications, corresponding author Dea Slade, together with first author Johannes Benedum and their team, investigated the paralogous proteins PHD finger protein 3 (PHF3) and Death-inducer obliterator (DIDO). They found that the proteins collaboratively regulate gene expression and that, intriguingly, transcriptional upregulation of DIDO3 can compensate for the loss of PHF3. Collaborators are the Zagrovic lab and the Akalin lab at the Berlin Institute for Medical Systems Biology.
Perutz group leader Shotaro Otsuka has received one of the most prestigious awards for researchers in Europe - the ERC Consolidator Grant. The total funding of €2 million over 5 years recognizes both Shotaro’s past achievements and future potential. The Otsuka lab is investigating the inter-organelle communication between the endoplasmic reticulum and the nucleus. The project “conNEctoER” aims to understand the structure and function of membrane connections that link the nucleus to the endoplasmic reticulum.
The Max Perutz PhD Fellowship honors the most ambitious and innovative PhD projects at the institute. This year’s awardees are Jeanne Fesselet (Kovarik lab) and Manuela Sophie Koller (Campbell lab). Their projects will investigate the role of mRNA decay in promoting plasticity of resident macrophages and the phenotypic effect of aneuploidy in yeast, respectively.
Congratulations to group leader Egon Ogris on being promoted to professor at the Medical University of Vienna.
Henry Thomas, formerly a PhD student in the Buecker lab, is among this year’s exceptional young scientists who have received the Vienna BioCenter PhD award. Henry is the 20th Max Perutz Labs student to receive the prize for their PhD work. In 2005, the prize was introduced by former Perutz group leader Renée Schroeder and acknowledges the best PhD theses across the four research institutes at the Vienna BioCenter. Among previous awardees are current Perutz group leaders Martin Leeb and Stefan Ameres.
Approximately one in eight men will be diagnosed with prostate cancer in his lifetime. Prostate cancer is commonly androgen addicted, in which case androgen receptor signal inhibitors (ARSI) can prolong survival. However, the cancer cells eventually develop resistance to ARSIs, resulting in poor clinical outcome. The molecular mechanisms underlying AR-mediated prostate cancer progression remain unclear. In a new study published in Nature Communications, co-corresponding author Egon Ogris and his team, together with collaborators from the University of Pennsylvania, the University of Michigan and the University Medical Center Hamburg-Eppendorf, show that leucine carboxy methyl transferase 1 (LCMT1) suppresses AR signaling and that its product, methylated protein phosphatase 2A (PP2A), is a valuable prognostic marker and potential therapeutic target.
The Max Perutz Labs are embedded in the Vienna BioCenter, providing access to outstanding core facilities shared by all members of the campus in addition to facilities unique to our institute.
With a strong molecular focus and a diversity of model organisms, we aim to bridge basic research with biomedicine.
To honour an extraordinary teacher and scientist, the Max Perutz Labs were named after Max Ferdinand Perutz, who, together with John C. Kendrew, was awarded the 1962 Nobel Prize in Chemistry for his studies on the structure of globular proteins ...
The Max Perutz Labs are an international research institution in which people from all over the world come together to conduct scientific research. The Perutz recognizes and respects diversity as an important asset in establishing an inclusive and productive work environment for all parties, may it be students, scientists or support staff. We are committed to a workplace that values diversity and internationality, where people from various backgrounds and perspectives feel welcome and are supported in a safe environment. Whether it be race, ethnicity, national origin, religion, social background, age, gender, sexual orientation or disability - we aim to establish a community in which everyone feels included and is treated fairly and respectfully. We believe that there is always room for improvement and that a statement is worth nothing without action, but we continuously strive to do better and encourage every individual to play an active role in creating this environment.
The Max Perutz Labs seek to educate students to think critically and analytically, challenge them to set ambitious goals, and instill in them both broad horizons and deep understanding. In doing so, we aspire to furnish them with the necessary knowledge and skills to push forward the frontiers of 21st century biomedical science.